SDCE holds classes at six main campuses as well as numerous off-campus locations.
| Name | Abbreviation | Address | Associated Campus |
|---|---|---|---|
| Saint Agnes Catholic Church | STAGN | 1145 Evergreen, San Diego, CA | West City |
| Salvation Army Community Center | SACCT | 4170 Balboa Ave., San Diego, CA | West City |
| Samahan Senior Community Center | SMSCC | 2926 Market St., San Diego, CA | Centre City |
| San Carlos Public Library | SCLIB | 7265 Jackson Dr., San Diego, CA | Mid City |
| San Carlos Recreation Center | SANCA | 6455 Lake Badin Ave., San Diego, CA | Mid City |
| San Carlos Village Apartments | SCVA | 7717 Tommy St., San Diego, CA | Mid City |
| San Diego Chinese Center | CHSCC | 428 3rd Ave., San Diego, CA | Centre City |
| San Diego County Board of Education | SDBDE | 6401 Linda Vista Rd., San Diego, CA | North City |
| San Diego County Dept of Health Services | CMHS | 3851 Rosecrans St., San Diego, CA | West City |
| San Diego County Health and Human Services Agency | SDDSS | 5201 Ruffin Rd., San Diego, CA | North City |
| San Diego County Housing Commission | SDCHC | 3989 Ruffin Rd., San Diego, CA | North City |
| San Diego County Operation Center Central Record | SDREC | 5555 Overland Ave., San Diego, CA | North City |
| San Diego Health and Human Services Agency | DSS | 5454 ruffin Rd., San Diego, CA | North City |
| San Diego Historical Society | HISTS | 1649 El Prado/Balboa Park, San Diego, CA | Centre City |
| San Diego Housing Commission | SDHCO | 2035 Alaquinas Dr., San Diego, CA | ECC ( Educational Cultural complex) |
| San Diego Intermediate Care Center | SDICC | 1119 28th St., San Diego, CA | Centre City |
| San Diego Police Dept Pistol Range | SDPDP | 4008 Federal Blvd., San Diego, CA | Mid City |
| San Diego Rescue Mission | SDMRM | 120 Elm St., San Diego, CA | Centre City |
| San Diego School of Creative and Performing Arts | SDSCP | 2425 Dusk Dr., San Diego, CA | ECC ( Educational Cultural complex) |
| San Diego Service Center for the Blind | SDBLD | 5922 El Cajon Blvd., San Diego, CA | Mid City |
| San Diego Unified Port District | SDUPD | 3165 Pacific Highway, San Diego, CA | West City |
| San Diego Urban League | SDUL | 4274 Market St., San Diego, CA | ECC ( Educational Cultural complex) |
| San Diego Youth Services | SDYTH | 2220 Broadway, San Diego, CA | Centre City |
| Santa Margarita Apartments | SANMA | 5369 Santa Margarita, San Diego, CA | ECC ( Educational Cultural complex) |
| Scripps Ranch High School | SCRHS | 10410 Treena St., San Diego, CA | North City |
| Scripps Ranch Library | SRLIB | 10301 Scripps Lake Dr., San Diego, CA | North City |
| Scripps Ranch Recreation Center | SRPRK | 11454 Blue Cypress Dr., San Diego, CA | North City |
| SD Marriott Hotel and Marina | SDMHM | 333 West Harbor Dr., San Diego, CA | Cesar Chavez |
| Senior Community Center S.D. | SENCC | 1335 3rd Ave., San Diego, CA | Centre City |
| Senior Community Centers of San Diego | SCCSD | 928 Broadway, San Diego, CA | Centre City |
| Sequoia Elementary Scholl | SEQOI | 4690 Limerick Ave., San Deigo, CA | North City |
| Serra High School | SERCA | 5156 Santo Rd., San Diego, CA | North City |
| Serra Mesa park and Recreation Center | SERME | 9020 Village Glen Dr., San Diego, CA | |
| Seventh Day Adventist & Church | IADSD | 2411 Broadway, San Diego, CA | Cesar Chavez |
| Sherman Elementary School | SHERM | 450 24th St., San Diego, CA | Cesar Chavez |
| Sherman Heights Community Center | SHCCT | 2258 Island Ave., San Diego, CA | Cesar Chavez |
| Skills Center | SKILS | 835 12th Ave., San Diego, CA | Centre City |
| Skyline Park and Recreation Center | SKYPR | 8285 Skyline Dr., San Diego, CA | ECC ( Educational Cultural complex) |
| Somali Youth and Education Center | SYCTR | 4844 University Ave., Suite #120, San Diego, CA | Mid City |
| South Clairemont Rec Center | SCREC | 3605 Clairemont Dr., San Diego, CA | West City |
| South Metro Career Center | SMCCT | 4389 Imperial Avenue, San Diego, CA | ECC ( Educational Cultural complex) |
| St Andrews Lutheran Church | STANL | 8350 Lake Murray Blvd., San Diego, CA | Mid City |
| St Davids Episcopal Church | STDAV | 5050 Milton St., San Diego, CA | West City |
| St Dunstans Episcopal Church | STDUN | 6656 Park Ridge Blvd., San Diego, CA | Mid City |
| St Elizabeths Episcopal Church | STELI | 2825 Merton Ave., San Diego, CA | North City |
| St Josephs Church | STJHC | 1535 3rd Ave., San Diego, CA | Centre City |
| St Judes Academy | STJUA | 1228 S. 38th St., San Diego, CA | ECC ( Educational Cultural complex) |
| St Lukes Episcopal Church | STLUK | 3725 30th St., San Diego, CA | Mid City |
| St Pauls Community Care Center | STPCC | 328 Maple St., San Diego, CA | Centre City |
| St Pauls Manor | STPLM | 2635 2nd Ave, San Diego, CA | Centre City |
| St Pauls Villa | STPAV | 2340 4th Ave., San Diego, CA | Centre City |
| St Vincent De Paul | STVIN | 4077 Ibis St., San Diego, CA | Centre City |
| St Vincent de Paul/Joan Kroc Center | KROCC | 1501 Imperial Ave., San Diego, CA | Cesar Chavez, Centre City |
| St. Michael's Parish Hall | STMP | 643 HOMEDALE ST., S, | ECC ( Educational Cultural complex) |
| St. Pauls Health Care Center | SPAUL | 235 Nutmeg St., San Diego, CA | Centre City |
| Standley Park and Recreation Center | STLYR | 3585 Governor Drive, San Diego, CA | West City |
| Stockton Recreation Center | STOCK | 415 31st St., San Diego, CA | Cesar Chavez |
| Summerville at Clairemont | CLMGR | 5219 Clairemont Mesa Blvd., San Diego, CA | West City |
| Sunrise Assisted Living | SRALV | 820 Turquoise St., San Diego, CA | West City |
| Sunrise Care Center of San Diego | SUNCC | 3022 45th St., San Diego, CA | Mid City |
| Sunrise Terrace Care Center | SUNTR | 5602 University Ave., San Diego, CA | Mid City |